高血压患者血小板α＿2肾上腺素能受体改变的临床意义

Clinical Significance of Changes in Platelet α_2 Adrenergic Receptor in Patients with Hypertension

采用放射性配基结合法及高压液相色谱法对原发性高血压（Ａ组，ｎ＝２４）继发性高血压（Ｂ组，ｎ＝１９）患者及正常对照组（Ｃ组，ｎ＝２６）的血小板α肾上腺素受体（ＰＬα_２－ＡＲ）及血浆儿茶酚胺（ＣＡ－去甲肾上腺素ＮＥ）水平进行测定，结果表明：Ａ组ＰＬα２－ＡＲ密度高于Ｃ组及Ｂ组，受体密度与血压及ＣＡ水平正相关。本研究表明ＰＬα２－ＡＲ密度的变化能反映原发性高血压病人的交感神经活性，并能反映家族遗传的特性，在高血压病的诊断与鉴别上有一定临床意义。

The platelet α2 adrenergic receptor(PL α2-AR)by using radioligand and binding technique and plasma catecholamine(CA-NE)by HPLC were determined in patients with essential hypertension (group A,n=24) and secondary hypertension(group B,n=19),and in normal control(group C,n=26).The results showed that PL α2-AR density in groupA (Bmax 246±11.6 fmol/mg protein)was much higher than that in the group C(Bmax 148±10.2 fmol/mg protein)and in group B(Bmax 112±10. 4 fmol/mg protein). The increase in PL α2-AR density is positively correlated with blood pressure and the level of plasma catecholamine. It is suggested that the changes in PL α2-AR density can represent the sympathetic activity and genetic characteristic in patients with essential hypertension. Determination of PL α2AR density may be of clinical significance in the differential diagnosis of hypertension.