生化指标用于矽肺早期诊断的探讨

Study on Biochemical Indices of EarlyDiagnosis of Silicosis

对Ｘ线诊断为矽肺Ⅰ期的３９名患者和３１名无尘肺０＋者进行了六项生化指标的测定，结果经方差分析，矽肺Ⅰ期组的血清铜蓝蛋白（ＣＰ）、超氧化物歧化酶（ＳＯＤ）测定值高于０＋组，血清丙二醛（ＭＤＡ）含量低于０＋组。逐步回归分析表明，以上三项指标有助于区分矽肺Ⅰ期和０＋。矽肺Ⅰ期组尿羟脯氨酸（ＨＹＰ）、血清铜、锌含量与０＋组无显著性差异。判别分析表明，血清ＣＰ、ＳＯＤ、ＭＤＡ三项指标建立的判别方程与矽肺Ⅰ期的Ｘ线诊断符合率为８９．７％，与０＋的Ｘ线诊断符合率为９１．４％。据此认为，血清ＣＰ、ＳＯＤ、ＭＤＡ可以做为辅助矽肺早期诊断的指标。

Six biochemical indices were determined,in 39 silicosis cases of“stage l”and 31 casesof “stage 0+”.The results of variance analysisshowed the activities of serum ceruloplasmin(CP)and superoxide dismutase(SOD)werehigher in cases of silicosis“stage Ⅰ”than incases of“stage 0+”,while the activity ofserum malondialdehyde(MDA) in cases of “stage Ⅰ”was lower than that in cases of“stage 0+”.The result of the stepwise re-gression,analysis indicated these 3 indiceswere helpful to differeniate the cases of“stage Ⅰ”from those of“stage 0+”,and therewas no significance difference between casesof “stage Ⅰ”and“stage 0+”in the levels ofurinary hydroxyproline(HYP) and serumtrace element Cu and Zn..The discriminationanalysis of serum CP,SOD and MDA showedthat the reliability rates of the discriminationequation of silicosis cases“stage Ⅰ”and in“stage 0+”were 89.7%and 91.4%,of radio-logical diagnosis respectively.According to allabove results, the levels of serum CP,SODand MDA may be used as supplementary in-dices for early diagnosis of silicosis.