维生素C和维生素E对六价铬致突变性影响的研究

Study of Effects of Vitamin C and E Mutagenicity of Hexavalent Chromium

以小鼠骨髓细胞染色体畸变率和睾丸细胞染色体畸变率为指标，研究了维生素Ｃ、维生素Ｅ及维生素Ｃ与维生素Ｅ协同作用对六价铬致突变性的影响。结果表明，大剂量的维生素Ｃ对六价铬有抗突变作用，维生素Ｅ对六价铬致突变作用无明显影响，维生素Ｃ与维生素Ｅ协同作用比单纯给维生素Ｃ抗六价铬诱变作用增强。

Effect of vitamin C and E on mutagenicity of hexavalent chromium were studied. The results showed that vitamin C had the antimutagenic effect against hexavalent chromium manifested by a decrease of the frequencies of chromosome aberration of hone marrow and testis cell,vitamin E had no significant antimutagenic effect against hexavalent chromiurn, but simultaneous vitamin C and E had a stronger antimutagenic effect against hexavalent chromium than only vitamin C.