摘要
应用小鼠Ｐ３８８实体瘤模型，进行了二乙基二硫代氨基甲酸钠（ＤＤＣ）增强平阳霉素（ＢＬＭＡ５）抗癌活性的实验。结果表明，在ＢＬＭＡ５１２ｍｇ／ｋｇ、１５ｍｇ／ｋｇ及２４ｍ／ｋｇ３个剂量组分别辅加５００ｍｇ／ｋｇＤＤＣ后，抑癌率明显高于单独用ＢＬＭＡ５的试验组。给小鼠ｉｐ５００ｍｇ／ｋｇ、７５０ｍｇ／ｋｇＤＤＣ，在３０ｍｉｎ、１ｈ、４ｈ时，受试小鼠的ＳＯＤ活性丧失至０，到２４ｈ时，ＳＯＤ活性才恢复到正常的４０％。结果提示，减少Ｃｕ２＋的水平及增加Ｏ＿２￣－的浓度可以修饰ＢＬＭＡ５的细胞毒性。
A transplanted P388 solid tumor modle was used to study the efficacy of bleomycin (BLMA5) and DDC combination treatment. The result ahowed that the antitumor effect of BLMA5 was signi ficantly increased when BLMA5 was used in combination with DDC as compared with BLMA5 alone (P<0.05 ). When 500mg/kg and 750mg/kg of DDC were injected into the mice,the SOD activity of the blood of the mice was decreased in 100% at 30 min. 1h and 4h. and only returned to 40% of normal by 24h after experiment. These results suggested that reducing Cu+2 level and increasing concentration might modify the cytotoxicity of BLMA5.
关键词
肿瘤
P388
平阳霉素
超氧化物歧化酶
DDC
P_(388) Tumor Diethyldithiocarbamate Bleomycin A_5 Superoxide dixmutase
