中国肾综合征出血热病人血清型研究

Study on Serotypes of Hantavirus Infection in China

总结中国大部分地区近年应用血凝抑制试验等方法检测肾综合征出血热病人血清型的初步结果，并用量化的方法进行了肾综合征出血热的疫区分型，结果表明中国大部分地区已经演变为混合型肾综合征出血热疫区，同时尚存部分姬鼠型和家鼠型肾综合征出血热疫区。近十年来，抽样监测表明，中国肾综合征出血热病人汉坦病毒Ⅰ型感染５０．０３％～５１．０８％，Ⅱ型占４８．９２％～４９．９７％。指出了血清型研究对指导防制实践，尤其是对当前合理选用疫苗具有重要指导意义。还提出了对人群致病的汉坦病毒属，不同种（型或亚型）的同源性大小，与鼠科和仓鼠科中的汉坦病毒主要宿主动物黑线姬鼠、褐家鼠、欧洲棕背、鹿鼠系统发育的远近，有密切的亲缘关系。

The preliminary study on serotypes of recent Hantavirus infection in most part of China was summarized. By mainly using hemoagglutionation inhibition test,the number and constitution of the Different serolypes of Hantavirus infection in nearlg every province and municipality directly under the central goverment were brought to light for the first time. It was also shown that the majority of epidemic areas of Hemorrhagic fever with renal syndrome (HFRS) in China had evolved into mixed type, though a few areas had kept its original single type. In recente ten years. sampling investigation on patients with HFRS in China showed that 50. 03% ～ 51. 08% were Hantaan(HTN)type, 48. 92 % ～ 49. 97 % were Seoul (SEO)type. The importance of study on serotypes of epidemic areas for the control of the disease,especially for the choose of the kind of vaccines against Hantavirus was pointed out. The relationship between the serotypes of HTN viruses and their host animals was discussed according to the systematic development and historical distribution of Apodemus agrarius .Rattus norvegicus, Peromyscus maniculatus and Clethrionomys glareolus.