摘要
应用小鼠骨髓微核试验染色体畸变分析、ＳＨＥ恶性转化试验及ＳＯＳ／Ｕｍｕ显色反应研究南四湖水样有机提取物的致突变性。结果表明。沙堤、薛排沟和下航道的水样有机提取物均有不同程度的致突变性，有致染色体断裂作用，高剂量组和阳性对照组均可见ＳＨＥ细胞的恶性转化，对ＤＮＡ具有直接损伤作用和细胞毒性。因此，可以认为南四湖已受到遗传毒性物质污染，具有致癌危险性。
Recent epidemiological stydies auggested that an association exists between Nan-si Lake water water and cancer mortality of residents in the Nan-si Lake area. Four mutagenicity tests were selected to detect the mutagenicity of the Nan-si Lake water. The results of mutagenicity tests show that the organic extracts of the Nan-si Lake water in Shadi, Xuepaigou. Xiahangdao districts gave positive results in mouse bonemarrow micronucleus test and chromosome aberration analysis. SHE test, SOS test. The micronucleus morphology was shown that organic extracts induced micronucleus by some genotoxic clastogeds. Malignant transformation of SHE cell was found in high-dose group and positive control group. SOS test showed immediate DNA damage by the Nap si Lake water. The results of this study suggest that that some mutagens or carcinogens exist in the Nan-si Lake water.
关键词
南四湖
水样有机提取物
致突变物
Nan-si lake Organir extracts of water Mutagens Carcinogens
