遗传因素与原发性高血压

Relationship between Genetic Factor and Essential Hypertension

为了探讨遗传因素与原发性高血压的关系，调查了３９个家系父母Ⅱ系Ⅲ级亲属及无血缘关系亲属１５岁以上成人共９３７人。结果表明：有血缘关系高血压患病率明显高于无血缘关系者，分别为３３．３９％和２２．１１％；不同亲属级别高血压患病率Ⅰ级＞Ⅱ级＞Ⅲ级＞一般人群；经Ｌｏｇｉｓｔｉｃ回归分析排除混杂因素后，遗传因素仍独立存在；以遗传因素为背景与其它几个重要危险因素相结合时，也均见到相加模型的增效作用；遗传与共同生活二因素经叉生分析，无论共同生活存在与否，遗传因素恒定存在。

In order to explore the relationship between the genetic factor and essential hypertension,39 probands and their first.second and third degree relatives as well as non-consanguineous relatives were investigated. A total of 937 individuals were concerned. The results were as follows: the prevalence rate of hypertension in consanguineous relatives was significantly higher than that of in non-consanguineus relatives, they were 33.39% and 22. 11% respectively. A significant prevalence gradient was observed, that was first-degree > seconddegree An third-degree>non-consanguineus relatives. The genetic factor was still of an important factor by unconditional logistic regression analysis after confounding factors had been excluded. An additive synergy model was found when the genetic factor combined with some other important factors.Stratified analysis between the genetic factor and shared life was showed that the genetic factor was important no matter shared life had or not.