骨痂中多核巨细胞与破骨细胞的组织学及超微结构观察

Multinclear giant cells and osteoclasts in callus -histological and ultrastructural observation

本文通过光镜与透射电镜对家兔桡骨标准分析模型骨痂内多核巨细胞与破骨细胞形态进行了观察。观察显示，两种细胞均参与骨吸收，但多核细胞主要在分析早期吸收死骨和骨碎屑，吸收方式包括吞噬和细胞外降解；破骨细胞主要吸收钙化软骨骨痂和新生骨小粱，通过细胞外吸收方式完成骨痂改建。作者认为，多核巨细胞表面的丝状伪足和破骨细胞表面的皱折缘与骨矿物质细胞外降解有关，但其降解机理的差别尚有待揭示。

The morphology of multinuclear giant cells (MGC) and osteoclasts (Oc) in rabbit's radius callus had been observed by light microscopy and transmission electron microscopy.It showed that both MGC and Oc participated in bone resorption, but MGCmainly resorbed dead bone and bone chips through phagocytosis and extracellular degradation at the early stage of fracturehealing, and Oc mostly resorbed calcified cartilaginous callus and new formed trabecular bone by extracellular resorption to accomplish the remodeling of callus. It is suggested that the filopods on the surface of MGC and ruffled border on the surface of Oc are closely related to extracellular degrdation of bone mineral. Their difference in the mechanism of degradation is waiting or further study.