摘要
用同位素标记法研究了[^3H]甘糖酯1次灌胃后在小鼠体内的药代动力学,其血药浓度-时间曲线符合一室开放模式。小鼠灌服[^3H]甘糖酯25mg/kg(4.48MBq/kg)后的药动力学参数为:t1/2Ka0.24h;t1/2β67h,Vd921mL,Cl9.58ml/h,AUC41.45mg/(mL·h),F79.3%,PPB54.9%。该药广泛分布于肝、肾、脾、胸腺、肾上腺、肺、心、肌肉和脑内。
The in vivo pharmacokinetics of Propylene Glycol Mannuratae Sulfate (PGMS) after acute administration in mice was studied by the radio isotope assay. Its concentration -time curve fitted the one -compartment model. The pharmacokinetic indice of oral administration of PGMS 25 mg/kg are as follow;t1/2 Ka 0. 24 h,t1/2 B 67 h,Vd 927 mL,C1 9. 58 mL/h,AUC 41. 45 ng/(ml - h), F 79. 3%,PPB (plasma protein binding) 54. 9%. The drug was widely distributed in the liver,kidney,spleen,thymus,adrenal gland,lung,heart, muscles and brain,and excreted mainly through urine and feces.
出处
《中国海洋药物》
CAS
CSCD
1995年第2期15-17,共3页
Chinese Journal of Marine Drugs
关键词
甘糖酯
药代动力学
吸收
分布
propylene glycol mannurate sulfate (PGMS)
pharmacokinetics
absorption
distribution
excreAon