甘糖酯在小鼠体内的药代动力学研究

STUDIES ON THE IN VIVO PHARMACOKINETICS OF PROPYLENE GLYCOL MANNURATE SULFATE IN MICE

用同位素标记法研究了［＾３Ｈ］甘糖酯１次灌胃后在小鼠体内的药代动力学，其血药浓度－时间曲线符合一室开放模式。小鼠灌服［＾３Ｈ］甘糖酯２５ｍｇ／ｋｇ（４．４８ＭＢｑ／ｋｇ）后的药动力学参数为：ｔ１／２Ｋａ０．２４ｈ；ｔ１／２β６７ｈ，Ｖｄ９２１ｍＬ，Ｃｌ９．５８ｍｌ／ｈ，ＡＵＣ４１．４５ｍｇ／（ｍＬ·ｈ），Ｆ７９．３％，ＰＰＢ５４．９％。该药广泛分布于肝、肾、脾、胸腺、肾上腺、肺、心、肌肉和脑内。

The in vivo pharmacokinetics of Propylene Glycol Mannuratae Sulfate (PGMS) after acute administration in mice was studied by the radio isotope assay. Its concentration -time curve fitted the one -compartment model. The pharmacokinetic indice of oral administration of PGMS 25 mg/kg are as follow;t1/2 Ka 0. 24 h,t1/2 B 67 h,Vd 927 mL,C1 9. 58 mL/h,AUC 41. 45 ng/(ml - h), F 79. 3%,PPB (plasma protein binding) 54. 9%. The drug was widely distributed in the liver,kidney,spleen,thymus,adrenal gland,lung,heart, muscles and brain,and excreted mainly through urine and feces.