金蒸气激光光敏疗法治疗膀胱癌的临床研究

Photodynamic Therapy of Bladder Cancer with a Gold Vapour Laser

报道经多种治疗后再生的膀胱癌患者７０例，共３１６个肿瘤，用光纤输出功率２Ｗ，带有球型弥散刀头石英光纤传输的金蒸气激光，通过膀胱镜作肿瘤及全膀胱血卟啉光敏治疗，经６～４６个月的随访，痊愈５４例，占７７．１４％，显效１２例占１７．１４％，好转４例，占５．７％，再生８例，占１１．４３％。

Seventy patients with 316 tumors of urinary bladder have been treated by photodynamic therapy (PDT) with a gold vapour laser. All cases were histopathologically diagnosed as transitional cell carcinoma. The power output from the tip of an optic fibre was 2.0￣2. 5 W and the power density used was 70. 8￣509. 6 mW/cm2. The pulse duration was 20-50 μs, the pulse energy was 0. 5 mJ per pulse and the repetition rate was of 6000￣9000 Hz. Both the tumors and whole bladder were irradiated. Hematoporphyrin derivative (HpD, Yanzhou Biochemical Pharmaceutics, China was given Ⅳ in a dose of 5 mg/kg in 250 ml of 5% glucose, 48 hours prior to irradiation. The results of a follow-up of 4￣46 months are as follows: cured, 54 case (77.14 % ) ; good effect, 12 (17.14 % ) ; and improved, 4 (5.7 % ). Tumor regrowth occurred only in 8 cases (11.43% ) within 3￣9 months after PDT. The results suggest an increase of cured ratio and a decrease of regrowth ratio and the reoccurrence ratio of tumors has compared with results obtained by other treatment modalities.