旋毛虫感染病兔抗体动态的研究

STUDIES ON THE ANTINBODY RESPONSE OF EXPERIMENTALLY-INFECTED RABBITS WITH TRICHINELLA SPIRALIS

以旋毛虫成囊期幼虫的盐水浸出液为抗原，用ＥＬＩＳＡ方法检测人工感染旋毛虫病兔ＩｇＧ抗体的反应动态。结果表明：１，特异性抗体水平与感染度呈正相关且重感染组的特异性抗体比轻感染组早３ｄ检出。２．抗体水平随感染时间的延长而增高，从感染后７７ｄ起明显下降但可持续４个月之久。

A crude saline extract of Trichinella spi-ralis larvae in muscle was used as antigen. Se-rial serum samples from experimentally in-fected rabbits with T.spiralis were examinedover four months for specific IgG hy ELISA.In experiments with rabbits infected with dif-ferent number of T. spiralis larvae.A positivecorrelation was found between initial dose oflarvae and antibody level detected by ELISA.Furthermore , the specific antibodies to T. spi-ralis in heavily-infceted rabbits were detected3 days earlier than those in ligbtly-infectedrabbits.The antibody response showed thatspecific antibodies increased with time afterthe infection ,but decreased considerably fromthe 77 th day after the infection. However,the antibody could last 4 mnonths.