甲苯达唑、阿苯达唑和吡喹酮对小鼠细粒棘球蚴囊壁丙氨酸转氨酶和天门冬氨酸转氨酶的影响（英）

EFFECTS OF MEBENDAZOLE,ALBENDAZOLE AND PRAZIQUANTEL ON ALANINE AMINOTRANSFERASE AND ASPARTATE AMINOTRANSFERASE OF ECHINOCOCCUS GRANULOSUS CYST WALL HARBORED IN MICE 

感染细粒棘球蚴达１０－１２个月的小鼠ｉｇ甲苯达唑（Ｍｅｂ）２５－５０ｍｇ·ｋｇ－１·ｄ－１×７－１４ｄ，其体内瘪囊壁与充盈囊壁的丙氨酸转氨酶（ＡＬＴ）抑制率为６７．８％－７８．９％和１１．３％－４５．４％，ｉｇ阿苯达唑３００ｍｇ·ｋｇ－１·ｄ－１×１４ｄ对充盈囊壁ＡＬＴ的抑制率为４０．７％，而ｉｇ吡喹酮５００ｍｇ·ｋｇ－１·ｄ－１×１４ｄ的则无明显影响。用上述药物治疗时，仅Ｍｅｂ５０ｍｇ·ｋｇ－１·ｄ－１组对天门冬氨酸转氨酶（ＡＳＴ）有抑制作用，抑制率为２６％－４３．９％。

Alanine aminotransferase(ALT) and aspartate aminotransferase (AST) of Echinococcus granulosus cyst wall harbored in mice for 10-12 months was measured.The activities of the 2 enzymes were 3 430±1 370-4 160±1 790 and 1 560±840-2 890±1 470,respectively.When infected mice were treated ig with mebendazole(Meb)25 mg·kg -1 ·d -1 for 7-14 d,or 50 mg·kg -1 ·d -1 for 7 d,the ALT activities of cyst walls of both collapsed and full cysts were inhibited significantly with average inhibition rates of about 50%。Another benzimidazole derivative,albendazole(Alb),also inhibited ALT activity of the cyst wall with an inhibition rate of 40.7%,but this was not the case in the treatment with praziquantel 500 mg·kg -1 ·d -1 of the infected mice for 14 d.When the infected mice were treated ig with the above mentioned drugs at the same regimens,no apparent effect on AST activities of the cyst wall was seen except for the group treated ig with Meb at a higher daily dose,the inhibition rates being 26%(collapsed cyst)and 43.9%(full cyst).The significance of the results has been discussed briefly.