米非司酮用于排卵期房事后避孕的子宫内膜形态学观察

the Period of Ovulation The Observation of the Endometrial Morphology Using Mifepristone as Postcoital Contraception in

为了解米非司酮用于排卵期房事后避孕引起的子宫内膜形态学改变,选择21名健康育龄妇女做为受试者,于排卵后72小时内口服300mg米非司酮。排卵后7～8天取内膜做常规光镜下观察。结果发现所有内膜改变都与原周期时相不同步。说明排卵后服用米非司酮使内膜所发生的形态学改变足以防止胚胎种植,故可作为一月一次排卵期房事后有效的避孕药物。

The purpose of the present study was to investigate the changes in endometrial morphology when mifepristone administration was used for postcoital contraception in the period of ovulation. Twenty-one healthy women were recruited. Mifepristone (300mg,orally)was given 72 hours apart after ovulation. An endometrial biopsy was taken on LH+7 - 8 day and observed in light microscope. The results revealed retaradation of endometrial development and endometrial dyssynchrony. When mifepristone was administered after ovulation, the morphologic changes are sufficient to prevent implantation. Mifepristione might be considered for use a once-a-month pill for postcoital contraception in the period of ovulation.