甲硝唑的单扫示波极谱分析

Single-Sweep Oscillopolarographic Analysis of Metronidazole

本文系统地研究了甲硝唑在汞电极上的电极过程，证明了该电极过程为一含有吸附作用的不可逆的扩散控制过程，电子转移数为４，不可逆系数ａ＝０．７１４．建立了甲硝唑的单扫示波极谱测定法，在０．２０ｍｏｌ／Ｌ的ＮａＣｌ溶液中，于－０．７１Ｖ（ｖｓＳＣＥ）处的峰高与浓度［（０．０２─８０）ｍｇ／Ｌ］间存在良好的线性关系，检测限为２．４μｇ／Ｌ，ＲＳＤ＝２．０％（ｎ＝８），并考察了人体内常见微量物质对的影响。

The electrode process of metronidazole (MTZ) on mercury electrode has been investigated systematically and proved to be a irreversible one controlled by diffusion with weak adsorpation. The number of electronic transfer is 4 and the irreversible coefficient (a) is 0.714. The peak height of the 2nd-order derivative cathodic wave (i″p) at -0.71 V vs SCE is of a good linear relationship with MTZ concentration in the range from 20 mg/L to 60 μg/ml. RSD is 2.0% (n=8), and the detection limit is 2.4 mg/L (S/N=2.5). The interference of micro-constituents existingin biological fluids on i″p was also studied.