脑缺血再灌对小鼠学习记忆的影响及药物防护

Protective effect of drug and influence of cerebral ischemia reperfusion on learning and rememberance in mice

在建立脑血管性学习记忆障碍模型的基础上，观察脑缺血再灌对小鼠学习记忆的影响及服用尼莫地平、７６４－３、醒脑灵对其的防护作用。重复脑缺血再灌可明显的降低动物的学习和记忆能力，并可通过药物改善小鼠学习记忆障碍的程度。

Based on the animal model of learning and rememberance disturbance induced by cerebral ischemia,the influence of cerebral ischemia reperfusion on learning and rememberance in mice and the protective effect of Nimodipine,764-3,Xingnaoling were observed.The results showed that repetitive ischemia might lower the ability of learning and rememberance and that Nimodipine,764-3, Xingnaoling could reduce the damage in learning and rememberance.Author's address: (Insititute of Basic Medical Sciences,Beijing,100005)