摘要
本文报道健康兔６只静注替考拉宁后的药物动力学。血药浓度用微生物法测定。单剂静注替考拉宁２０ｍｇ／ｋｇ后，体内药物转运过程符合二室开放模型。静注后即刻血药浓度为１４１．１１±４２．０３μｇ／ｍｌ，分布相半衰期为０．１０±０．０３小时，消除相半衰期为３．４８±０．６５小时。表现分布容积为０．１３±０．０３Ｌ／ｋｇ。药时曲线下面积为１７５．６１±１８．９８ｈ·μｇ／ｍｌ，总清除率为０．１１±０．０２Ｌ／（ｈ·ｋｇ）。
Teicoplanin is a new glycopeptide antibiotic with good antibacterialactivities againet Gram-positive bacteria. The pharmacokinetics of teicoplanin was studied in six rabbits after single dose adminstration of 20 mg/kg intravenously. The serum concentrations of the drug were determined by micro-bioassay method.The serumconcentration-drug profiles conformed to the two-compartment open model.After intravenous injection,the immediate mean peak level was 141.11 ± 42.03μg/ml.The distribtition half life was 0.10± 0.03h,which stiggests that the drug be distributed within the body rapidly。The elimination half life was 3.48±. 65h
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第1期48-50,共3页
Chinese Journal of Antibiotics
