环丙沙星滴耳液对内耳影响的研究

Experimental study on the auristilla ciprofloxacin to inner ear of guinea pig

豚鼠中耳（听泡）内滴入０．５％、１％、２％环丙沙星与庆大霉素滴耳液７天或２１天，借助光镜和扫描电镜观察内耳的显微和超微结构变化。结果证明环丙沙星对内耳没有明显的毒性作用。庆大霉素则使耳蜗明显受损，以底回为重，Ｃｏｒｔｉ’ｓ器外毛细胞坏死较多，内毛细胞及支持细胞病变较轻。位觉斑耳石脱落，毛细胞纤毛粘连、脱落。壶腹嵴中央区纤毛也缺失。本实验对客观评价环丙沙星对内耳的作用及临床使用提供了形态学资料。

or 2 percent solution of ciprofloxacin and gen tamicin wereinjected once a day for 7 days or 21 days into the middle ears(balla tympanic)of healthyguinea pigs。All these animals were decapitated at the end of experiment.The pathologicalchange in microstructure and ultrastructure of inner ear was examined by light microscopyand scanning electron microscopy.The findings revealed that the inner ear are littleclamaged in the groups of ciprofloxacin。But the cochleas of GM were servely damaged,particularly in bassal truns。The outer hair cells in Corti’s organ were clestroyed tO a greaterextent while inner hair cells and supporting elements were preserved.Simultaneously,degenerated otoliths and fusing stereocilia appeared in the utricular and saccular macule andthe loss of sensory cilia in the central part of crista ampullaris。This experiment presents anobjective evaluation on the ototoxicity and morphological data of auristilla ciprofloxacin forthe clinical treatment of ear diseases。