手术病人组织中头孢曲松和庆大霉素的浓度

The efficacy of ceftriaxone and gentamicin for prevention of infection in surgery patients

３３例手术病人，分别静滴头孢曲松（１２例）及庆大霉素（２１例）。手术前、后取切口组织测定其药物浓度，同时进行药动学研究。分析了１９２个组织样品（头孢曲松７０个，庆大霉素１２２个），头孢曲松组织样品有９１％高于ＭＩＣ５０，庆大霉素组织样品只有２６．２％高于ＭＩＣ５０。头孢曲松的半衰期为１２．８１±５．４５ｈ庆大霉素的半衰期为１１．３４±４．８９ｈ．

patients were given ceftriaxone (12 patients ) and gentamicin (21patients) intravenously. The drug concentrations in incisions tissues and serum before andafter operation were determinated by HPLC. The T1/2 of ceftriaxone and gentamicin were12. 81 ±5. 45 and 11. 34 ±4.89h, respectively. All the serum drug concentrations ofceftriaxone and gentamicin were higher than MIC50. But 91% tissue drug concentrations ofceftriaxone were higher than MIC50,compared to only 26. 2% of gentamicin were higher thanMIC50. The tissue drug concentrations responsing the antimicrobial activity of antibiotic atsite, it suggested that gentamicin was less effective for prevention infection in surgerypatients .