摘要
用反相高效液相色谱法建立了血浆中的己酮可可碱的定量分析方法。该方法是以非那西丁为内标参照物，采用液相提取预处理血样，己酮可可碱与非那西丁彼此分离良好，在５－４００μｇ／ｌ的浓度范围，线性关系良好，最低检测浓度为５ｇ／ｌ。并应用本法对正常人静脉点滴已酮可可碱（舒安灵）进行药代动力学研究。
A reversed phase liquid chromatographic method for quantitative determination of pentoxifylline(PT)in plasma was established.The blood plasma sample detection was pretreated by liquid-liquid extraction. Phenacetin was used as internal standard.Calibration curves in the range 5-400μg/l for pentoxifylline was linear. The lower limit of detection for pentoxifylline in plasma is 5 μg/l. The pharmacokinetic characteristics of pentoxifylline in normal subjects after a single intravenously administered was investigated by the method.
出处
《中国临床药理学杂志》
CSCD
北大核心
1995年第2期107-110,共4页
The Chinese Journal of Clinical Pharmacology
