幼年类风湿性关节炎患儿细胞及体液免疫的改变

CELLULAR IMMUNITY AND HUMORA IMMUNITY IN JUVE-NILE RHEUMATOID ARTHRITIS

用单克隆抗体测定了１７例幼年类风湿性关节炎患儿外周血中Ｔ淋巴细胞亚群的含量，结果显示ＣＤ３细胞，ＣＤ４细胞及ＣＤ４／ＣＤ８与正常对照组比较存在显著性差异，ＣＤ８细胞无统计学意义。提示了幼年类风湿性关节炎存在有细胞免疫功能紊乱。同时还观察到消炎痛治疗本病对Ｔ淋巴细胞亚群无影响。并且观察了血清免疫球蛋白，发现ＩｇＧ高于正常对照组，ＩｇＭ和ＩｇＡ无显著性差异。

Peripheral blood T lymphocyte subsets of seventeen children with juvenile rheumatoid arthritis (JRA) were measured. The result showed that CD3 cells, CD4 cells and CD4/CD8were increased and CD8 cell were not varied. Meanwhile these patient serum immuoglublin-G(IgG) were increased and had statistical difference. This result was caused by cellular immuni-tydisorder.