大黄素、丹参素对单核细胞分泌炎性细胞因子的调节

THE INFLUENCE OF EMODIN AND DANSHENSU ONMONOCYTE’S SECRETION OF INFLAMMATORY CYTOKINES

用生物学方法观察了中药有效成分大黄素及丹参素对单核吞噬细胞的调节作用。分别观察了其分泌肿瘤坏死因子α（ＴＮＦ＿α）、白细胞介素１、６、以（ＩＬ－１，ＩＬ－６，ＩＬ－８）的变化。结果发现，大黄素和丹参素分别能激活单核吞噬细胞分泌上述４种炎性细胞因子，同时还能抑制由内毒素诱导的上述因子的分泌。另外还发现，虽然大黄素和丹参素能激活单核吞噬细胞分泌细胞因子，但所产生的量均显著低于由内毒素诱导所产生的量。因此，推断大黄素和丹参素可能具有两方面的调节作用。一方面能抗炎，另一方面能增强机体的免疫功能。

or further study the mechanism of traditional chinese herbs of eliminating the stagnantand activating the blood circulation’we observed the regulatory founction of emodin and dan-shensu on mononuclear phagocytes,human monocyte and Balb/c mice peritoneal macrophage,secreting TNF_α,IL-1,IL-6,IL-8. As the result,we found emodin and danshensu could inhibitmononuclear phagocytes to secret inflammatory cytokines induced by endotoxin. We also foundemodin and danshensu could stimulate mononticlear phagocytes to secret inflammatory cytokinesbut the amount vvas lower than that indticed bv endotoxin.