甲状腺疾病患者血清可溶性白细胞介素2受体测定的临床意义

CLINICAL SIGNIGICANCE OF THE DETERMINATIONS OF SOLU-BLE INTERLEUKIN-2 RECEPTON(sIL-2R)IN THE PATIENTSWITH THYROID DISEASES

某些甲状腺疾病时血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平及其与游离甲状腺素（ＦＴ＿４）、游离三碘甲腺原氨酸（ＦＴ＿３）和促甲状腺素（ＴＳＨ）水平的相关性比较。结果发现甲状腺机能亢进症（甲亢）未治疗组（Ａ）及甲亢未治疗伴突眼组（Ｄ）血清ｓＩＬ－２Ｒ明显升高；甲状腺机能减退症（甲减）经治疗甲状腺功能灭常组（Ｇ）ｓＩＬ－２Ｒ明显高于甲减未治疗组（Ｆ）；１０例毒性弥漫性甲状腺肿（Ｇｒａｖｅｓ病）患者经抗甲状腺药物治疗后ｓＩＬ－２Ｒ明显降低；Ｇｒａｖｅｓ病及甲减患者血清ｓＩＬ－２Ｒ均与ＦＴ＿３呈正相关。提示除自身免疫外，甲状腺素水平也是甲状腺疾病患者血清ｓＩＬ－２Ｒ水平的重要调节因素。

The results of determinations of soluble interleukin- 2 receptor(sIL-2R)and FT_3、FT_4、TSH were reported in patients with thyroid disorders. One hundred and fifteen patients withGraves’disease were devided into 5(A,B,C,D,E)groups and twenty-three patients with by-pothyroidism were devided into 2(F,G)groups according to their clinical features and thyroidfunctions. The levels of sIL-2R were higher in untreated Graves’ disease(group A)and un-treated Graves disease with ophthalmopathy(group D) than other groups. The leves of sIL-2Rof patients with hypothyroidism(group G),who were treated and their thyroid function becamenormal , were higher than those hypothyroid ism patients(group F ) who were untreated. Thelevels of sIL-2R were reduced to normal in 10 patients with Graves’ disease who vvere treatedand their thyroid functions became normal. High significant positive correlation between FT_3and sIL-2R was found in patients with Graves’ disease(r=0. 433, P <0. 001) and with hy-pothyroidism(r=0. 534, P <0. 02). It suggests that thyroid hormons are main regulator ofthe concentrations of serum sIL-2R in patients with thyroid disorders. The contribution of au-toimmune activity maybe detected only in some patients with Graves’ disease with ophthamopa-thy,while the role of the immune system is masked by the hyperthyroid state.