γ－干扰素和白细胞介素－4在支气管哮喘发病中作用的研究

THE EFFECT OF INTERLEUKIN-4 AND AND INTERFERON-γ ON THEPATHOGENESIS OF ASTHMA

阐明ＩＦＮ－γ和ＩＬ－４在支气管哮喘发病中的作用。选择了急性发作期和缓解期病人及正常人各２０例作为研究对象。实验结果表明，急性发作期病人的ＩＬ－４分泌细胞明显高于缓解期和正常对照组，病人血清总ＩｇＥ也高于正常对照组，但在两组病人之间无明显差异。ＰＨＡ－诱导的ＩＦＮ－γ活性在病人和正常对照组之间也无明显的差异。值得注意的是，在急性发作期病人，ＩＦＮ－γ和ＩＬ－４之间，ＩＦＮ－γ和血清总ＩｇＥ水平之间存在着负相关。进一步表明由于病人体内ＩＦＮ－γ和ＩＬ－４之间的不平衡是引起哮喘发作和血清ＩｇＥ升高的重要原因。

he role of IL-4 and IFN-γ in the pathogenesis of asthma were studied. 20 acute attack,20remission asthma and 20 normal controls were studied. The results showed that the IL-4 produc-ing cells in acute attack group were higher than those in remission group and controls. The IgEproducing were higher in patients than those in normal controls,but no difference between acuteattack patients and remission patients. The PHA-induced IFN-γ production were no differencebetween patients and controls. In acute attack patients,a negative correlation was found betweenIFN-γ and IL-4,also there was an inverse relation between IFN-γ and IgE production.