摘要
应用酶联免疫吸附法及间接微固相放免法对比检测了扩张型心肌病（ＤＣＭ）患者血清的抗心肌线粒体腺苷酸转位酶自身抗体，发现两种方法检测的结果基本一致。ＤＣＭ患者抗腺苷酸转位酶抗体的阳性率为４２％，而冠心病及正常人群未发现此抗体。ＤＣＭ患者血清中抗腺苷酸转位酶抗体滴度随时间推移而逐渐降低。抗腺苷酸转位酶抗体的研究可能在扩张型心肌病发病机理及早期诊断上具有重要价值。
e
investigeted the frequancy and dynamic change of auto-antibody
against the adenine nu-cleotide translocator (ANT) in dilated
cardiomyopathy (DCM) by using enzyme-linked im-munosorbent assay and
indirect micro-solid-phase radio-immunoassay.A significant
antibodytitre was seen in 10 of 24 DCM patients. in comparison,sera
from patients with coronary heartdisease were within montrol range.
The titre of anti-ANT antibody in DCM patients decreacedgradually in
three months follow-up. Anti-ANT antibodies may play a fundamental
role in thepathogenesis of DCM.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1995年第3期173-175,共3页
Chinese Journal of Immunology
基金
国家青年自然科学基金
关键词
心肌病
抗腺苷酸转位酶
ELISA
自身抗体
Dilated cardiomyopathy
Auto-antibody against adenine nucleotide translo-cator Enzyme-linked
Immunosorbent assay
