摘要
对采用主动免疫治疗获成功的２２对原因不明性习惯性流产夫妇，作了治疗前后患者抗丈夫淋巴细胞毒抗体和混合淋巴细胞培养（ＭＬＣ）观察。发现治疗后大部分患者没有出现抗丈夫淋巴细胞毒抗体，提示细胞毒抗体与治疗是否成功无必然联系。ＭＬＣ结果表明，主动免疫治疗在患者中诱发了免疫抑制，且这种抑制是非特异针对丈夫的。因为治疗后，患者对丈夫，患者对无关男性的ＭＬＣ刺激指数均显著下降，同时伴有血清抑制因子升高，两者与治疗前相比均有显著差异（Ｐ＜０．０１）。提示细胞免疫参与了免疫抑制。诱发免疫抑制可能是主动免疫治疗获得成功的机制之一。
22 patients
withrecurrent spontaneous abortions who had live virth following
immunotherapy were investigated。 The results showed that the mixed
lymphocyte cultures(MLC)of patientsto partners and patients to
unrelated men were all significantly decreased after
immunization(P<0. 001 and 0. 01 ) It suggests that immunosuppressions
were induced by the immunotherapyand the suppressions were not specmc
to partners. Furthermore,the serums from patients afterimmunization
inhibited the MLCs significantly compared with before
immunzation(P<0. 01)。As most of patients treated with lymphocytes
from unrelated donors did not show maternal anti-paternal
lymphocytotoxic antibodies after immunotherapy, the immunosuppressive
factors in pa-tients serums might be cytokines secreted from
suppressor cells.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1995年第4期235-238,共4页
Chinese Journal of Immunology
关键词
流产
免疫抑制
免疫疗法
细胞免疫学
Recurrent spontaneous abortion
Immunotherapy Immunosuppression
