不育的免疫性因素分析研究

EMMUNE FACTORS OF INFERTILITY AND RECURRENT SOPON- TANEOUS ABORTION

应用ＢＡ－ＥＬＩＳＡ法分析了４４７对不育夫妇男女双方血清及宫颈粘液中精子抗体及女方血清中透明带抗体。结果显示，不孕组与精子抗体及透明带抗体的发生明显相关。无论是血清中还是宫颈粘液中精子抗体仅与原发性不孕相关；而与继发性不孕及反复自然流产无明显关系。透明带抗体与不孕及反复自然流产均有关，因此，透明带抗体比精子抗体在更大范围内影响人类生育。

ntisperm antibodies and ai1tizona pellucida antibodies were investigated in 447 couples ofinfertility and recurrent spontaneous abortion ( RSA ),healthy fertile women as controls,It wasfound that both primary and secondary infertility were significantly related to antisperm and antizona pellucida antibodies. The antisperm antibodies in sera and cervical mucus were only relat-ed to the primary infertility,but not to the secondary infertility and the RSA。 The antizona pel-lucida antibodies were in relation to all the sterile groups。 It suggested that the antizona pellucidaantibodies influeiice human fertility in larger range than the antisperm antibodies.