摘要
用皮质酮造成大鼠细胞免疫抑制模型,观察右归饮的调节作用,结果表明:模型大鼠免疫功能明显抑制,淋巴细胞增殖反应减弱.NKCC活性降低,IL-2、IFN-Y含量减少。200%右归饮灌胃(10g/kg)后,可以有效拮抗CORT对细胞免疫的抑制,体内和体外试验均可见模型大鼠淋巴细胞增殖反应加强,NKCC活性提高,IL-2和IFN-γ水平也明显提高,文章对其可能作用机理作了初步分析。
An experimental mdeel of the cellular immunity of rats inhibited by
corticosterone(CORT)was established and then we observed the
regulation of YOU GUI YIN(YG)on the cellular im-munity of rats
inhibited by CORT. The results showed that the immune function was
obviouslyinhibited in the model.The proliferative reaction of
lymphocyte diminished and Natural-KillerCell
Cytotoxicity(NKCC)decreased,The level of IL-2and IFN-γ
declined,After administered200%YG(10g/kg)to the experimental group,it
was found the YG could antagonised the inhi-bition of cellular
immunity caused by CORT effectively. Both of the proliferative
reaction of lym-phocyte and NKCC of the model raised in vivo and
vitro. The level of IL-2 and IFN-γ increasedobviously in vivo.The
probable mechanism of YG have been discussed in this paper。
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1995年第4期248-252,共5页
Chinese Journal of Immunology
基金
国家自然科学基金
国家教委博士点基金及日本养命酒制造公司中央研究所经费的资助
关键词
皮质酮
细胞免疫
细胞因子
右归饮
药理
Corticosterone Cellular immunity Cytokine YOU GUI YIN..