肝癌用药物输注装置作肝动脉灌注的观察

OBSERVATIONS ON HEPATIC ARTERY INFUSION USINGDRUG DELIVERY SYSTEM FOR LIVER CANCER

本文介绍６６例中晚期肝癌埋置药物输注装置作肝动脉和门静脉灌注化疗的长期随访结果。治疗组２９例均为不能切除的肝癌；预防组３７例为姑息性肝切除术后。结果：治疗组中完全缓解２例，部分缓解１１例，轻度缓解４例，无改变１０例，病情发展２例，总有效率４４．８％（１３／２９），中位生存期１５月，二期切除率１３．８％（４／２９）。预防组中肝动脉灌注组无复发，最长已观察５３月；而３例门静脉主干癌栓取出后单作门静脉灌注者均复发，术后１、２、３年生存率分别为６５．７％、５０％、２５％。

AbstractHepatic Artery infusion (HAI) and/or portal vein infusion (PVI) chemotherapy usingdrug delivery system for 66 patients with middle or late stage liver cancer and their long-termresults are reported. Of these, 29 patients were unresectable liver cancer (therapeuticgroup ) , 37 patients had palliative hepatectomies (Preventive group). The results of thera-peutic group : complete regression in two patients , partial regression in 11, mild regressionin 4, no change in 10, and progressive disese in 2. The total effective rate was 44. 8 % (13/29) , the medium survival time was 15 months. The two stage resection rate was 13. 8% (4/29). For the preventive group, there was no recurrence after HAI. The longe observationtime was 53 months. Recurrence was detected in all 3 patients treated with PVI after tumoremboli enucleation. The 1 ,2 ,3-yr survival rates were 65. 7% , 50%, 25% respectively.