恶性阻塞性黄疸患者引流术前后免疫功能变化和血清白细胞介素Ⅱ受体检测意义的研究

PRE-AND POSTOPERATIVE IMMUNE FUNCTIONIN PATIENTS WITH MALIGNANT OBSTRUCTIVEJAUNDICE AND THE SIGNIFICANCE OF SERUM SIL-2R

本文观测１８例恶性阻塞性黄疸患者胆道引流术前１天、术后１、３、７、１４和２１天免疫功能变化。另设２０例良性阻塞性黄疸患者为对照。结果显示：总补体、补体Ｃ３参与术后的炎症反应；ＳＩＬ－２Ｒ术后先上升后下降，而后又再次上升，表明减黄术对改善恶性阻塞性黄疸患者免疫功能有效；ＳＩＬ－２Ｒ为一敏感指标。

n this study, the immune function in 18 patients with malignant obstructive jaundicewas observed before and after bile duct drainage. Other 20 patients with benign obstructivejaundice were served as control. The results revealed that: total complement and C3 partookthe. inflammatory reaction , they reached the peak on the 3rd postoperative day ' there was nosignificant differences between these two groups ; no significant change was noted in C4 levelafter bile duct drainage in both groups. The change of soluble interleukinZ receptor (SIL-ZR) was simalar with lymphocyte tranformation rate (LTR). SIL-2R in malignant groupwas significantly higher than that in benign group,it reached the peak on the 3rd postopera-tive day in both groups and subsequently decreased,after that increased again on 14th post-operative day in the malignant group. This may indicate that drainage plays a role of improv-ing the immune function in malignant obstructive jaundice and SIL-2R is a sensitive marker.