旋毛虫病人治疗后血清抗体水平的变化

Serum Antibody Levels in Human Trichinosis after Therapy with Albendazole

应用旋毛虫幼虫冰冻切片抗原间接荧光抗体试验（ＩＦＡＴ）观察了旋毛虫病人阿苯哒唑治疗后血清抗体水平的变化。结果表明，治疗后抗体阳性率及抗体滴度均比治疗前明显升高，此现象可作为一种治疗有效的客观指标。此外，对旋毛虫病人及时治疗也可将检测到抗体的时间提前１～２周。旋毛虫病人从治疗后１个月开始抗体水平明显下降，至治疗后４个月时抗体转阴率已达７５％。因此，ＩＦＡＴ对旋毛虫病的近期及远期疗效考核均有一定价值。

serum antibody levels in patients with trichinosis after therapy with albendazole were observed by indirect fluorescent antibody test(IFAT)using frozen sections of Trichinella spiralis larvae as antigen. The results showed that the antibody positive rate and antibody titer of the patients with trichinosis after therapy were obviously higher than that before therapy. The phenomena could be considered as a objective criterion of effective treatment for trichinosis. Otherwise,the antibody detection time was one to two weeks aheadof time. The antibody levels began to fall evidently 1 month after therapy, the antibody negative rate was up to 75% 4 months after therapy. Hence, it was reasonable to consider that IFAT was of certain value for checking up the short-term and the long-term therapeutic effect of human trichinosis.