重症肌无力患者体感诱发电位的研究

M-SEP studies in myasthenia gravis

３０例ＭＧ患者作了正中神经Ｍ－ＳＥＰ额顶同步描记，有延髓以上ＣＮＳ功能异常１４例（４６．７％），以一侧Ｐ２２波ＡＭＰ降低或消失最多见。８例治疗后复查，７例的异常恢复，１例临床好转但ＥＰ未变且对侧又异常。胸腺瘤术后３月始恢复。６例原ＥＰ正常者治疗后复查有１例一度又有异常。异常主要与症状及胸腺瘤有关。与ＥＥＧ结果比较一致，但阳性率明显为高。认为此项检查有助探讨ＭＧ的ＣＮＳ损害和指导治疗。

Simultaneous parieto-frontal recording of M SEP was performed in 30 cases of MG. 14 cases(6.7%) showed unilateral lowered Amp or absence of wave p22, which indicated CNS involvement above medulla oblongata. Reexamination of M-SEP in 8 cases showed that 7 restored normal. However, only 1 remained unchanged and even with contralateral abnormal changes in spite of clinical improvement,but 3 onths after removal of thymus tumor the reord of M-SEP restored normal. Besides. the reexamination of the other 6 noraml EP cases showed a transient change in 1 cases. The abnormal EP was only related to the severeness of the disease and presence of thymus tumors. It was in coincidence with EEG findings although the abnormality rate was significantely higher than that of EEG. The results suggested that this technique is useful for the study of CNS involuement and the instruction of clinical therapy of MG.