透明质酸钠置换眼房水及其毒性试验

Aqueous Humor Replaced and Acute Toxicity Tests of Sodium Hyaluronate

报道透明质酸钠急性毒性试验和置换兔眼房水的眼毒性试验。临床观察手术后 4 wk,用眼压等测定和眼球病理组织学检查进行系统研究,证明没有毒性。

Acute toxicity test of sodium Hyaluronate(HA) in mice was carried out .and aqueous humor of rabbit eyes was replaced with HA to evaluate its ocular toxicity. Clinical observation of the mice and the rabbits was carried out. After four weeks, the systemic influences of HA on this animals were studied by intraocular pressure determination and palhologicai histology examinations. No toxicity was observed.