黄体功能不全与生殖激素的关系

Relationship between luteal phase defect and reproductive hormones

本文对22例有排卵不孕妇女于 B 超监测排卵的同时,在卵泡中期、围排卵期和黄体中期测血清 LH、FSH、PRL、E_2、P、T;排卵后第10～14天取子宫内膜行病理学检查。按子宫内膜发育落后于月经周期>2天判断为黄体功能不全(LPD)。比较 LPD 组(n=12)和正常组(n=10)生殖激素值与卵泡直径的差异。结果;FSH 和卵泡期 LH、E_2在两组间无差异,黄体期 LH、E_2、P 水平,LPD 组低于正常组(P<0.05);而 PRL、T 水平,LPD 组均高于正常组(P<0.05)。正常组卵泡直径大于 LPD 组(P<0.05)。结果提示 LPD 的发生与高 PRL、高 T 及黄体期低 LH 有关;卵泡发育不成熟也是 LPD 的原因之一。

Serum LH,FSH,E_2,P,T,and PRL were measured during mid-follicular,periovulatory and middle luteal phase of the menstrual cycle,and B ultrasound were performed for detection of ovulation in 22 ovula- tory infertile women.Luteal phase defect(LPD)was definedas endometrial development being more than 2 days out of phase on biopsy.Comparison between the LPD group (n=12) and the normal group (n=10) showed no difference in terms of serum FSH,LH, and E_2 levels in follicular phase (P>0.05).However, in luteal phase,serum levels of LH,E_2,and P in LPD group were lower than in normal group(P<0.05 )whearas PRL and T levels in LPD were higher than in normal group(P<0.05),and the follicular size in LPD group was smaller(P<0.05).The results indi- cated that development of LPD was associated with high levels of PRL,T and low LH in the luteal phase.Abnormal follicuiogenesis may be another causitive factor for LPD.