人血清羧基端甲状旁腺激素放射免疫测定的生理和临床意义

PHYSIOLOGICAL AND CLINICAL SIGNIFICANCE OF RIA MEASUREMENT FOR HUMAN SERUM CARBOXYL-TERMINAL PARATHYROID HORMONE

放射免疫测定232例正常人和121例各类疾病患者血iPTH浓度发现:正常人iPTH含量随年龄、性别不同而变化,特别指出造成41～50岁年龄组男女iPTH含量有显著性差异(P<0.05)的生理原因是女性更年期到来。测定iPTH对诊断原发性甲旁亢、尤其是定位诊断异位甲状旁腺腺瘤有独特临床价值,iPTH含量变化也是判断肾功能不全程度的一项客观指标,对骨质疏松发病原因的鉴别有一定参考价值。

Two hundred and thirty-two normal subjects who ranged in age from 11 to 88 years and 121 patients were measured the serum immunoreactive parathyroid hormone (iPTH) by a radioimmunoassay. Results indicate the serum iPTH changes with age and sex in normal subjects. Because of menopause, there were significant increase in women than in men from age of 40 to 50 years. There was an important value in diagnosis of primary hyperparathyroidism, especially in localization of ectopic parathyroidism. Serum iPTH level was an objective standard to evaluate chronic renal insuficiency, and was also a reference to evaluate pathogenesis of osteoporosis.