摘要
25例Ⅱ型糖尿病病人用吡磺环已脲治疗,每天剂量5～30mg,持续追踪观察6个月,总有效率为88％。治疗前后吡磺环己脲-葡萄糖介导胰岛素分泌面积无改变,但葡萄糖介导胰岛素分泌面积、胰岛素敏感性和葡萄糖利用常数(K_I)明显升高。提示该药的降糖作用除刺激胰岛B细胞分泌胰岛素、改善葡萄糖介导胰岛素分泌外,还改善机体对胰岛素的敏感性。
Twenty-five type II diabetics failed to be controlled by diet therapy alone were treated with glipizide and followed-up for 6 months. The daily dose of glipizide ranged from 5-30 mg. The excellent or good glycemic control occurred in 88% and 72% of the patients respectively. No hypoglycemia and other side effects were observed. The areas of glipizide-glucose mediated insulin secretion did not show significant change before and after glipizide therapy, but the areas of glucose-mediated insulin secretion, the insulin sensitivity, and the glucose disposal constant(KI)were significantly higher after glipizide therapy. Our study indicated that the hypoglycemic effect of glipizide was not only due to improved islet B cell function in insulin secretion, but also due to enhanced insulin-induced glucose utilization and insulin sensitivity.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1989年第1期17-19,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
吡磺环己脲
糖尿病
胰岛素分泌
Glipizide Type II diabetes mellitus Insulin secretion Glucose disposal constant (KI).
