血清TSH受体抗体检测对预测Graves病复发的意义

THE ESTIMATION OF SERUM THYROTROPIN RECEPTOR ANTIBODY IN PREDICTING THE RECURRENCE OF GRAVES' DISEASE

采用酶免疫法(EIA)测定和观察Graves病人血清TSH受体抗体(TRAb)在用他巴唑治疗过程中的变化并对部分病例停药后随访2年的结果表明,(1)治疗1年时血清TRAb持续存在的患者具有反覆发作的倾向。(2)停药时TRAb阳性是患者尚未达到免疫学缓解、可能在近期内复发的重要标志。

An EIA for detecting serum TSH receptor antibody (TRAb) was performcdin thepatients with Graves' disease (GD) during methimazole therapy. The results suggested that (1) Persistence of TRAb after one year treatment may predict a tendency of subsequent relapse. (2) A positive TRAb at the end of treatment, which may imply that GD patient has not acquired remission immunologically, is a good indicator of coming relapse.