鸡传染性贫血病毒感染对雏鸡免疫系统的影响Ⅱ．几种细胞因子体外诱生活性动态变化

Influence of Chicken Infectious Anemia Virus Infection on the Immune System in ChicksⅡ.Dynamic Changes of Activity Induction of Several Cy- tokines In Vitro

１日龄雏鸡人工感染鸡传染性贫血病毒（ＣＩＡＶ）后７、１４ｄ，脾脏Ｔ淋巴细胞ＩＬ－２活性明显降低（Ｐ＜０．０１，Ｐ＜０．０５），２１ｄ明显回升，２８ｄ显著升高（Ｐ＜０．０５），３５ｄ后降至对照水平；感染后７、１４和２１ｄ，胸腺Ｔ淋巴细胞ＩＬ－２诱生活性明显降低（Ｐ＜０．０５），２８ｄ后恢复至对照水平。感染后７、１４ｄ，脾脏淋巴细胞ＩＦＮ诱生活性明显低于对照鸡（Ｐ＜０．０５），２１ｄ后恢复至对照水平。感染后１４ｄ，胸腺淋巴细胞集落刺激因子（ＣＳＦ）诱生活性未见明显变化，２１ｄ显著升高（Ｐ＜０．０５），２８ｄ降至正常水平。

Studies were conducted to determine the changes of activities of inter-leukine-2(IL-2), interferon (IFN)and colony-stimulating factor (CSF)in splenic andthymic lymphocytes from chicks following infection with chicken infectious anemia virus(CIAV)at one day of age. The results were as follows :IL-2inductive activity in lym-phocytes from both thymus and spleen were significantly decreased in comparison withcontrols 7-21 days and 7-14 days post infection (PI),respectively(P < 0.01,P<0.05 ).IFN inductive activity was lower in splenic lymphocytes from CIAV-infectedchicks than from controls 7-14 days PI (P<0.05).No significant changes of CSF activi-ty from thymic lymphocytes were recorded 14 days PI, but CSF activity was significant-ly increased above control levels 21 days (P<0.01).The results suggested that CIAVinfection in chicks can introduce a dramatic decrease in molecular immunoregulation inboth primary and secondary immune organs.