摘要
对58例NIDDM患者以自行制备的特异抗血清用酶联免疫法测定Lp(α)水平,用多元逐步回归、分层切割抽样比较等方法,研究糖脂代谢紊乱控制程度及慢性合并症对Lp(α)水平的影响。结果发现:NIDDM全组Lp(α)水平增高(P<0.05),但这增高主要是慢性合并症组Lp(α)水平增高的结果;合并症组Lp(α)水平显著高于无合并症组(P<0.01);空腹血糖(FPG)水平和Lp(α)水平呈一定的正相关,且随FPG的增高,Lp(α)水平有增高趋势。结果提示NIDDM慢性合并症和糖代谢紊乱控制程度可在一定程度上影响Lp(α)水平。
Lipoprotein (α) [Lp (α)] was measured by enzyme-linked immunoassay with specific anti-Lp(α) serum in 58 cases of NIDDM and 42 age matched normal controls. It was found that:①serum Lp(α) level in NIDDM as a whole was higher than that in normal controls (P<0.05), but the difference between NIDDM without chronic complications and normal controls was not significant statistically.②Lp(α) level in NIDDM with chronic complications was higher than that in NIDDM without chronic complications (P<0.01). ③Lp (α) level was positively related to FPG level in NIDDM (r=0.303,P<0.03) and its increase with increment of FPG was significant statistically (P<0.05). The results indicated that in addition to the genetic factor, Lp(α)level in NIDDM was affected by chronic complications and degree of control of disturbance in carbohydrate metabolism.
出处
《中国糖尿病杂志》
CAS
CSCD
1995年第2期65-68,共4页
Chinese Journal of Diabetes