EGF在糖尿病足坏疽治疗中的应用研究

Research on treatment of diabetic foot by EGF

根据表皮生长因子（ＥＧＦ）能启动细胞生长的有关基因、促进表皮细胞生长的原理，在８例糖尿病足坏疽患者中，实验组５例外用ＥＧＦ；对照组２例用６５４－２，１例用０．９％盐水。对照组在上述药物治疗效果不明显时改用ＥＧＦ。８例患者１３个创面用ＥＧＦ后第３～５天皮肤生长，经８～６２天创面愈合。临床和实验证明ＥＧＦ有明显促创面皮肤生长作用。

According to the theory that epidermal growth factor (EGF) can initiate some genes relating to cell growth and promote proliferation of the epidermal cells,eight patients with diabetic foot were selected to treat with EGF. Among them, five patients as an experimental group were treated externally with EGF,and three patients as a control group treated with 654-2 in 2 cases and 0.9% saline in l case,but later changed to EGF because of no obvious improvement with 654-2 or saline. The results showed the skin of the 13 wound areas in the 8 patients began to grow on the 3rd-5th day after treatment with EGF, and the wounds healed in 8￣62 days.Therefore,the clinical results proved that EGF had a significant effect on promoting growth of skin, and was much better than that of 654- 2.