生长抑素在急性颅脑损伤中的意义

Significance of somatostatin in acute brain injury

用放免法测定３１例急性颅脑损伤患者脑脊液（ＣＳＦ）中生长抑素（ＳＳ）的含量。结果：脑外伤后４８ｈＣＳＦ中ＳＳ含量明显低于对照组（Ｐ＜０．０１），伤后６～１０天ＳＳ浓度升高，与对照组相比无明显差异。ＧＣＳ≤８分者ＣＳＦ中ＳＳ含量显著低于ＧＣＳ＞８分者（Ｐ＜０．０５）；上消化道出血组ＳＳ低于非出血组（Ｐ＜０．００５）。提示：ＳＳ可能参与了急性颅脑损伤的发病过程。ＳＳ水平降低可能与间接诱发急性上消化道疾病之间存在着某种联系。

The levels of somatostatin(SS)were determined byradioimmunoassay in the cerebrodpinal fluid(CSF ) of 31patients with acute brain injury.48 hrs after brain in-iury,the levels of SS in the CSF were significantly lowerthan the control group(P<0.01).6一10 days after braininjury,the levels of SS rose and there was no differencecompared with the control group.The levels of SS in GCS≤8 group were significantly lower than GCS>8group(p<0.05).Thje levels of SS in patients woth hem- orrhage of upper digestive tract were lower than the pa-tients without the disease(P<0.05).It is suggested thatSS may be invulved in the mechanism of acute brain in-jury and the decrease of SS levels may be related to the-indirect induction of the disease of upper digestive tract.