急性中毒患者血浆肾素血管紧张素Ⅱ醛固酮含量的测定及其临床意义

Determination of plasma renin,angiotensin Ⅱ and al-dosterone in acute poisoning and its clinical signiffi-cance

测定了３７例急性中毒患者（其中乙醇中毒１４例，安定中毒１１例，胃肠炎型食物中毒１２例）的血浆肾素（ＰＲＡ）、血管紧张素Ⅱ（ＡＴ－Ⅱ）和醛固酮（ＡＬＤ）含量，并与正常人对照。结果：急性中毒患者血浆ＰＲＡ、ＡＴ－Ⅱ、ＡＬＤ水平常呈升高现象（Ｐ＜０．０５或＜０．０１）；且升高与中毒时间呈负相关；乙醇和安定中毒组较胃肠炎型食物中毒组升高较为明显；ＰＲＡ、ＡＴ－Ⅱ、ＡＬＤ随病情的加重而升高，ＡＴ－Ⅱ与ＰＲＡ、ＡＬＤ呈正相关（Ｐ值均为Ｐ＜０．０１）。提示：血浆ＰＲＡ、ＡＴ－Ⅱ、ＡＬＤ含量可作为急性中毒病情判断及疗效考核的有意义的监测指标。作者对中毒过程中ＰＲＡ、ＡＴ－Ⅱ、ＡＬＤ变化规律的机制进行了探讨。

Plasma renin(PRA),angiotensin Ⅱ(AT-Ⅱ)a ndaldosterone(ALD)were determined in 37 cases of actitepoisoning ,including 14 cases of alcohol poisoning,11 cas-es of diazepam poisoning,12 cases of food poisoning(gastroenteritis type),and normal controls.It was foundthat the concentrations of PRA, AT-Ⅱ and ALD in a-cute poisoning were usually increased(P<0.05 or <0.01)and the elevation was negatively correlated withthe poisoning time.In addition, their elevation in the al-cohol poisoning group and the diazepam poisoning groupwas more significant than that of the food poisoninggroup(gastroenteritis type ). Also,PRA, AT-Ⅱ andALD were elevated with aggravation of the disease.AT-Ⅱ was positively correlated with PRA and ALD(P<0.01 ).It is suggested that PRA,AT-Ⅱ and ALD canbe used as a monitoring measure in the assessment of theseverity of the disesase and the therapeutic effectiveness.The mechanism of the changes of PRA, AT-Ⅱ andALD in the development of poisoning was discussed.