赤芍对油酸致成人呼吸窘迫综合征治疗作用的观察

Observation of red peony root in treatment of adult res-piratory distress syndrome induced by oleic acid/

以１６只健康杂种犬随机分成两组，组Ⅰ为对照组，油酸（ＯＡ）＋生理盐水；组Ⅱ为处理组，ＯＡ＋赤芍（ＲＰＲ）。中心静脉注入油酸，３０ｍｉｎ后静注赤芍注射液。结果：两组均在注ＯＡ３０ｍｉｎ后出现成人呼吸窘迫综合征（ＡＲＤＳ），６０ｍｉｎ后组Ⅱ动脉血氧分压（ＰａＯ＿２）、心脏指数（ＣＩ）及血液氧输送（ＤＯ＿２）较组Ⅰ显著升高，１２０ｍｉｎ后，组Ⅱ肺动脉平均压（ＰＡＭＰ）、肺循环阻力指数（ＰＶＲＩ）、肺分流率（Ｑｓ／Ｑｔ）及肺死腔率（Ｖ＿Ｄ／Ｖ＿Ｔ）显著低于组Ⅰ（Ｐ＜０．０５或＜０．０１）。两组肺毛细血管楔压（ＰＣＷＰ）、平均动脉压（ＭＡＰ）以及氧利用（ＶＯ＿２）差异无统计学意义。提示：ＲＰＲ能显著改善油酸所致ＡＲＤＳ的血流动力学、肺及血液的氧合功能。

Sixteen healthly dogs were randomly divided intotwo groups :group 1(control group)in which oleic acidand physiological saline were given;group 2(treatmentgroup)in which oleic acid(OA)and red peony rcot(RPR)were given。30 minutes after OA was given,RPR was in-jected intravenously。Results:30 minutes after OA wasinjected, model of adult repiratory distress svndrome(ARDS)appeared in the two groups, 60 minutes afterOA was injected, PaO_2,cardiac index(Cl)and oxygendelivery( DO_2)in group s were much higher than thdsein group 1,120 minutes after OA was given,pulmonaryarterial mean pressure ( PAMP),pulmonary vascular re-sistance in dex(PVRI),pulmonary shunt rate(Qs/Qt)and pulmonary dead space(V_D/Vt)in group 2 decreasedsignificantly as compared with those in group1 (P<0.05or<0.01).pulmonary capillary wedge pressure(PCWP),mean arterial pressure(MAP)and oxygen consunption(VO_2)had no significant differences between the twogroups(P>0.05). It is suggested that RPR can effective-ly improve hemodynamics and oxygenation of the lungand blood,in dogs with ARDS induced by OA.