枢复宁改良用法控制化疗所致的胃肠道反应

CLINICAL OBSERVATION ON ANTIEMETIC EFFECT OF ONDANSETRON DURING CHEMOTHERAPY BY MODIFIED METHOD OF ADMINISTRATION

采用自身对照方法观察５５例应用枢复宁及胃复安控制化疗所致胃肠道反应的效果。第１周期胃复安与化疗日期同步应用，第２周期枢复宁只在化疗ｄ１应用。结果显示枢复宁在各组方案及含顺铂方案控制急性呕吐有效率分别为９６．４％和８２．８％，明显优于胃复安组（Ｐ＜０．０１）；对于迟发性呕吐有效率在各组化疗方案ｄ２～ｄ５二者无差异（Ｐ＞０．０５），含顺铂方案ｄ２枢复宁优于胃复安（Ｐ＜０．０５），ｄ３～ｄ５无差异（Ｐ＞０．０５）。以上止吐效果与文献中报道一致。胃复安组副反应发生率为３４．５％，枢复宁为９．１％。

Self-comparision study on the efficacy of Ondansetron and Me-toclopramide during chemotherapy induced gastroenteric reaction were conductedin 55 patients. Results showed that Ondansetron is more effective than Meto-clopramide in actue emesis with a effective rate of 96.4% for patients receiv-ing regiment without Cisplantin and 82.8% for patients receiving regimentwith Cisplantin. But for delayed emesis the efficacy of the two has no signifi-cant difference except that in patients receiving regiment with Cisplantin. On-dansetron is better than Metoclopramide in the next day.