思增(SAIZEN)治疗生长激素缺乏症21例

REPORT ON TREATMENT OF 21 PATIENTS WITH GROWTH HORMONE DEFICIENCY WITH SAIZEN

应用哺乳动物细胞重组的人生长激素思增(Saizen)治疗21例诊断明确的生长激素缺乏症患儿,时间为半年。使用剂量为0.08IU/(kg·d)。治疗前及治疗后3、6月和停药后3月的生长速度分别为2.6±1.0、12.8±4.2、8.5±3.0和5.7±3.1cm/年(均与治疗前比P<0.01)。身高SDS治疗前为-5.4±1.2,治疗后6月为-5.0±1.2(P<0.01)。血清IGF-l的水平治疗前为0.275±0.103U/ml,治疗后6月为0.375±0.155U/ml(P<0.05)。治疗过程中无1例产生抗生长激素抗体。有5例(23.8％)在治疗过程中出现甲状腺功能减退,均及时补充甲状腺激素予以替代。

Growth hormone deficiency is a kind of disease caused by partial or complete deficiency of growth hormone. We have treated 21 cases of GH deficiency with mammalian cell recombinant human growth hormone (Saizen)for half a year . The dosage used was 0. 08IU/ (kg·d). The height velocity increased from 2. 6±1. 0 cm/year to 12. 8 ±4. 2 cm/year and 8. 5 ± 3. 0 cm/year during 3 and 6 months treatment respectively (P<0. 01, all versus before treatment). 3 months after the end of the treatment period,the velocity decreased to 5. 7±3. 1 (P<0. 01 vs before treatment). The height SDS improved from -5. 4±1. 2 before treatment to -5. 0±1. 2 (P<0. 01) during 6 months treatment. Serum IGF-I levels also increased from 0. 275±0. 103U/ml before treatment to 0. 375±0. 155 U/ml (P<0. 01). 5 cases (23. 8%) developed hypothyroidism during treatment which were replaced by thyroid hormone.