阿莫罗芬治疗甲癣和其它浅部真菌感染

TREATMENT OF ONYCHOMYCOSIS AND OTHER SUPERFICIAL FUNGAL INFECTIONS BY AMOROLFINE

阿莫罗芬具有抑杀真菌的两种活性。其体外抗真菌谱包括皮肤癣菌、双相菌、某些暗色丝孢霉、丝状真菌和酵母菌。临床试用５％阿莫罗芬甲漆剂外涂１～２次／周，用药６个月，对轻症甲癣停止治疗后间隔３个月，真菌学和临床治愈率约为４０％～５０％。用０．２５％阿莫罗芬霜治疗浅部真菌病外用１次／ｄ，用药６周总的治愈和显效率约为８５％～９０％。两种制剂的耐受性均良好，仅有轻度的局部副作用，故本药主要适应症是局部外用治疗甲癣。

Amorolfine is a topical antifungal agent with both fungistatic and fungicidal activities。In our clinical trial patients with mild onychomycosis were treated with 5%amorolfine nail lacquer once to twice weekly for 6 months and a cure rate of about 40%～55%were obtained 3 months after stop of therapy。Patients with superfi-cial dermatomycoses were treated with 0.25%amorolfine cream once daily for 6 weeks with a total response rate of about 85%～90%。Both preparations appear to be well tolerated with minor side effects.Onychomycosis appears to be the potential indication for the 2 preparations。