癫痫对大鼠光辨别学习及心脑组织中P物质含量的影响

The effect of epilepsy on light discrimination learning and the contents of substance P in brain and heart of rats

本研究在遗传性听源性癫痫大鼠模型上，采用了行为和放射免疫分析相结合的方法，研究了大鼠癫痫发作对光辨别学习的影响及心脑组织中Ｐ物质含量的改变。癫痫发作后，大鼠光辨别学习能力明显减弱；表现为达到学会标准所需的时间明显延长（Ｐ＜０．０１），达标率明显降低（Ｐ＜０．０１）；大鼠下丘脑、海马中Ｐ物质的含量明显降低（Ｐ＜０．０１），而颞叶皮层和心脑组织中Ｐ物质含量明显增高（Ｐ＜０．０５～０．０１）；大鼠光辨别学习能力下降的同时，下丘脑、海马中Ｐ物质含量明显降低，而颞叶皮层和心脑组织中Ｐ物质含量明显增高（Ｐ＜０．０５～０．０１）。

The effect of epilepsy on light discriminarion learning and the contents of substance P(SP) were studied by means of behavior and radiommunoassay in genetically epilepsy prone rats,with a model of audiogenic epilepsy.The results were as follows:(1) The ability of light discrimination learning was significantly weakened after epilepsy seizure. It showed that the reaching the standard was markedly prolonged(P<0.01).and the rate of reaching learning standard was decreased(P<0.01).(2) The contents of SP in hypothalamus and hippocampus were significantly decreased (P<0.01). but inceased in cerebral cortex and myocardium after epilepsy seizure(P<0.05-0.01) (3) While the ability of learning of rats was weakened following epilepsy seizure, the contents of SP in hipothalamus and hippocampus were significantly decreased, but increased in cerebral cortex and myocardium (P<0.05-0.01).The results indicate that epilepsy seizure weakened the learning abilty of rats.The effect may be related to SP in these regions.