摘要
为探讨糖皮质激素对巨噬细胞功能的影响，观察了地塞米松对巨噬细胞产生氧自由基和一氧化氮的作用。结果表明地塞米松明显抑制巨噬细胞杀伤念珠菌以及抑制巨噬细胞产生氧自由基（Ｐ＜０．０１），减少内毒素诱导的一氧化氮生成（Ｐ＜０．０１）。提示了地塞米松抑制巨噬细胞杀菌功能的机制。
To explore the effect of corticosteroids on the function of peritoneal macrophage. the ability of macrophage to produce oxgen-derived free radicals and nitric oxide after using Dexamethasone was observed. The results showed Dexamethasone inhibited the production of oxygen-derived free radicals and nitric oxide from macrophage induced by zymosan and endotoxin. suggesting corticosteroids impaired antimicrobial activity of peritoneal macrophages.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第5期406-408,共3页
Chinese Pharmacological Bulletin
关键词
氧自由基
地塞米松
巨噬细胞
一氧化氮
oxygen-derived free radicals
Dexamethasone
macrophage
nitric oxide
