摘要
研制了两种不同基质的环内沙星栓剂，并对其在家兔体内的药物动力学与市售片剂进行了比较。实验表明，两种栓剂的Ｃ＿（ＰＫ），ＡＵＣ值等均明显高于片剂（ｐ＜０．００１），预示可以通过改变给药途径提高环丙沙星的生物利用度。
Two kinds of ciprofloxacin hydrochloride(1) suppositories were prepared, and their pharmacokinetics were compared with its tablets in rabbits.The results showed that the C_(max) and AUC of the suppositories were much higher than the tablets (p<0.001). Thus the bioavailability of 1 might be increased by changing its dosage form.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1995年第1期6-9,共4页
Chinese Journal of Pharmaceuticals
关键词
环丙沙星
栓剂
药物动力学
生物利用度
ciprofloxacin
suppository
pharmacokinetics
bioavailability
bioassay
