大白鼠脑移植体血管重建的观察及其意义

The observation and its significance of revascularization in grafted brain tissue of rats

本文观察了胎鼠脑组织移植大鼠眼前房及脑内后,移植体血循环的重建。移植后1、3、6个月进行切片染色,观察移植体的形态结构及血管构筑。结果表明,存活的脑移植体,重建血循环,但移植体的血管密度低于宿主相应的脑组织,微循环的形态不够完善,血循环不如宿主脑组织充分。个别脑移值体内未见血管长入,其神经细胞变性或消失。部分标本中可见慢性排异反应。结果提示,移植体血循环的建立是移植成功的关键。

Transplantation of fetal rat brain tissue into the anterior chamber of eye ball or cerebral hemisphere of the adult rats were performed.1, 3 and 6 months later the transplantated,tissue blocks were removed, and studied morphologically. Some animals were injected with ink for observing vascular architecture. The results show that the new capillarys of hosts extending into the blocks. However,the capillary density of the blocks was less than other brain tissue of the hosts;the blood circulation of the grafts was not so sufficient as that of the hosts.In a few experimental rats…… there were no capillary in the blocks and the neurons atrophied and disappeared. It might be concluded that establishment of blood circulation of the blocks is the key of success in brain transplantation.Occasionally, chronic immunological rejection changes was found in the graft tissue.