牛磺酸对大鼠应激性胃溃疡的影响及机制探讨

The effect of taurine on stress gastric ulceration

本文利用脑室微量注射法探讨了中枢牛磺酸在大鼠应激性胃溃疡中的作用，并同时利用放射免疫分析技术测定了部分脑区及血浆内神经降压素含量的变化，结果表明：（１）例脑室注射牛磺酸后，可明显减轻大鼠应激性胃粘膜损伤，（２）侧脑室注射牛磺酸后，垂体下丘脑内神经降压素含量明显增加，而大鼠血浆及皮层内神经降压素含量无明显改变。提示中枢牛磺酸具有细胞保护作用，其机制与神经降压素的合成或释放有关。

The effect of taurine on stress gastric ulceration was studied by ways of microinjection into the ventricle.At the same time we measured the contents of neurotensin(NT)in some brain areas and plasma by means of radioimmunoassay.The results are as follows,(11)The gastric lesion induced by stress became much less extensive after taurine was injected into ventricle.(2)The contents of NT in pituitary and hypothalamus increased markedly,but there is no change in cortex and plasma.This indicates that taurine has a cytoprotective effect and its effect may related to the synthesis and release of NT.